Débora Nascimento began her acting career in film as the protagonist of the short film Cérbero, by director Gastão Coimbra; and on television, in the telenovela Paraíso Tropical, as Elisa. Her natural beauty garnered attention and she had a role in the North American production of the film The Incredible Hulk. In the same year, she was featured in the telenovela, Duas Caras as Andréia Bijou.
In 2008 the actress particpated in a sensual photo-shoot for the magazine, UM (Universo Masculino). In 2009, along with actress Grazi Massafera, she starred in an advertising campaign for L'Oréal Paris.